Table 4.
CD4 cell count and HIV VL stratified by lymphoma subtype before or at ART start date, NA-ACCORD (N = 717)
| Features | Number of patients | TCL and NK/TCL | BL | PCNSL | DLBCL | P * |
|---|---|---|---|---|---|---|
| CD4 (cells/µL) | Total (n) | 25 | 64 | 29 | 257 | |
| <200 (n) | 12 | 25 | 23 | 150 | .002† | |
| >200 (n) | 13 | 39 | 6 | 107 | ||
| Median (IQR) | 214 (47-377) | 236 (145-416) | 56 (14-179) | 148 (55-316) | <.001† | |
| VL (copies/mL) | Total (n) | 24 | 64 | 23 | 241 | |
| <500 (n) | 4 | 5 | 1 | 12 | .12‡ | |
| ≥500 (n) | 20 | 59 | 22 | 229 | ||
| Median (IQR) | 56 163 (12 758-164 204) | 55 469 (15 047-144 419) | 118 000 (62 668-260 849) | 89 678 (21 828-318 419) | .03 | |
| Total (n) | 22 | 62 | 22 | 234 | ||
| CD4 ≥200/µL and/or VL <500 copies/mL (n) | 12 | 40 | 5 | 93 | <.001† | |
| CD4 <200/µL and VL ≥500 copies/mL (n) | 10 | 22 | 17 | 141 | ||
The CD4 cell count and VL exhibited here represent values measured closest to before or at ART start date.
P values for the comparison between patients in different lymphoma groups (Burkitt’s, PCNSL, DLBCL, and TCL and NK/TCLs) were calculated using Kruskal-Wallis and χ2 tests for non-normally distributed continuous variables and categorical variables, respectively.
Bonferroni-adjusted P values for pairwise comparison: CD4 cell count <200 vs >200: Burkitt’s vs PCNSL: .004, median CD4 cell count: Burkitt’s vs PCNSL, DLBCL: <.001, .006, Median VL: PCNSL vs DLBCL: .02, CD4 ≥200 and/or VL <500 vs CD4 <200 and VL ≥500: Burkitt’s vs PCNSL, DLBCL: .01, .005.
P values based on Fisher’s exact test because of some small cell counts.