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. 2022 Feb 25;6(5):1381–1393. doi: 10.1182/bloodadvances.2021004615

Figure 6.

Figure 6.

Two months of E-64 treatment of SS mice from 1 to 3 months of age shows increased trabecular and cortical bone thickness when analyzed at 3 months of age. (A) Representative three-dimensional heat maps of the epiphyseal region in SS 3-month-old mice administered saline or E-64 for 2 months, beginning at 1 month of age. A pseudocolor scale of blue (0 mm) to red (0.2 mm) depicts trabecular thickness. Trabecular bone parameters of trabecular thickness and BMD generated by microCT scans. (B) Representative three-dimensional heat maps of the mid-diaphyseal region in SS 3-month-old mice administered saline or E-64 for 2 months. A pseudocolor scale of blue (0 mm) to red (0.2 mm) depicts cortical thickness. Cortical bone parameters of cortical thickness, BA, BA/TA, and BMD generated by microCT scans. Data are expressed as mean ± standard deviation. Statistical significance, * P < .05, scale bar, E-64 or saline treated mice compared via t test. SS = black, SS with E-64 = red (n = 6-9 mice per group). Bone Min. Den., BMD; HA, hydroxyapatite.