Table 1.

Association of MTHFR rs1801133, CBS rs115742905, PT rs1799963, COL1A1 rs1107946 and rs2412298, COL2A1 rs121912891 and rs387906558 with Legg–Calvé–Perthes Disease

SNP and model	Genotype	Controls n (%)	Cases n (%)	OR (95% CI)	p value#	OR (95% CI)*	p value*
MTHFR rs1801133
	T/T	15 (32.6%)	6 (26.1%)	1.00		1.00
Codominant	C/T	21 (45.6%)	9 (39.1%)	1.07 (0.31–3.66)		0.43 (0.08–2.30)
	C/C	10 (21.7%)	8 (34.8%)	2.00 (0.53–7.54)	0.51	3.69 (0.56–24.56)	0.07
Dominant	T/T	15 (32.6%)	6 (26.1%)	1.00		1.00
	C/T-C/C	31 (67.4%)	17 (73.9%)	1.37 (0.45–4.19)	0.58	0.97 (0.23–3.99)	0.96
Recessive	T/T-C/T	36 (78.3%)	15 (65.2%)	1.00		1.00
	C/C	10 (21.7%)	8 (34.8%)	1.92 (0.63–5.81)	0.25	5.62 (1.02–30.93)	0.038
CBS rs115742905
	T/T	46 (100.0%)	23 (100.0%)	Monomorphic SNP		Monomorphic SNP
	T/C	0 (0.0%)	0 (0.0%)
	C/C	0 (0.0%)	0 (0.0%)
PT rs1799963
	G/G	46 (100.0%)	23 (100.0%)
	G/A	0 (0.0%)	0 (0.0%)	Monomorphic SNP		Monomorphic SNP
	A/A	0 (0.0%)	0 (0.0%)
COL1A1 rs1107946
	G/G	21 (45.6%)	13 (56.5%)	1.00		1.00
Codominant	G/T	13 (28.3%)	6 (26.1%)	0.75 (0.23–2.45)	0.63	0.73 (0.22–2.42)
	T/T	12 ((26.1%)	4 (17.4%)	0.54 (0.14–2.03)		0.53 (0.14–2.00)	0.62
Dominant	G/G	21 (45.6%)	13 (56.51%)	1.00		1.00
	G/T-T/T	25 (54.4%)	10 (43.5%)	0.60 (0.17–2.11)	0.41	0.63 (0.23–1.75)	0.38
Recessive	G/G-G/T	34 (73.9%)	19 (82.6%)	1.00		1.00
	T/T	12 (26.1%)	4 (17.4%)	0.60 (0.17–2.11)	0.41	0.59 (0.17–2.10)	0.41
COL1A1 rs2412298
	C/C	39 (84.8%)	19 (82.6%)	1.00		1.00
	C/T	7 (15.2%)	4 (17.4%)	1.17 (0.31–4.50)	0.82	1.18 (0.31–4.55)	0.81
COL2A1 rs121912891
	G/G	46 (100.0%)	23 (100.0%)	Monomorphic SNP		Monomorphic SNP
	G/A	0 (0.0%)	0 (0.0%)
	A/A	0 (0.0%)	0 (0.0%)
COL2A1 rs387906558
	G/G	46 (100.0%)	23 (100.0%)	Monomorphic SNP		Monomorphic SNP
	G/A	0 (0.0%)	0 (0.0%)
	A/A	0 (0.0%)	0 (0.0%)

Significant values are shown in bold

*Adjusted by age

^#Raw data