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. 2022 Mar 9;14:28. doi: 10.1186/s13073-022-01032-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Replication of cis-pQTLs. The percentage of replication of previously reported cis-regulated proteins between our analysis and three previous studies: Sun et al. [22], Suhre et al. [23], and Deming et al. [24]. For each dataset, the percentage of replication (y-axis) as a function of the significance threshold (x-axis) was computed as the number of cis-regulated proteins reported in this work that were also reported in the corresponding dataset as cis-regulated (the “replicated” proteins) divided by the total number of proteins reported as cis-regulated in a previous study that were analyzed in our work (the “replicable” proteins). The dashed vertical lines represent the p-value significance threshold corresponding to the FDR of cis-pQTLs (red) and to the nominal replication threshold (orange)