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. 2022 Mar 9;14:28. doi: 10.1186/s13073-022-01032-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Clinical relevance of pQTLs and associated genes. Enrichment in GWAS hits (orange) of cis-pQTLs (A—left) and trans-pQTLs (B—left) in comparison with, respectively, 10,000 randomly sampled set of cis-SNPs matched by MAF (bins of 5%) (A—right) and 10,000 randomly sampled set of trans-SNPs matched by MAF (bins of 5%) (B—right). Empirical resampling p-values are shown