Table 2.

Prognostic factors for radiotherapy response

Variables	No. (%)	Univariate		Mulitivariate
		OR (95% CI)	p value	OR (95% CI)	p value
Sex		0.91 (0.42–2.0)	0.813
Male	120 (69)
Female	54 (31)
Age		2.68 (1.25–5.78)	0.012
≤ 68	81 (46.6)
> 68	93 (53.4)
ECOG		0.84 (0.31–2.27)	0.725
ECOG 0–1	140 (80.5)
ECOG 2–3	34 (19.5)
Primary location		0.25 (0.11–0.58)	0.001
Renal pelvis	87 (53)
Ureter	77 (47)
Multifocality		0.62 (0.22–1.76)	0.368
Yes	23 (13.2)
No	151 (86.8)
Tumor size		0.8 (0.34–1.91)	0.615
< 4 cm	59 (46.8)
≥ 4 cm	67 (53.2)
Radical nephroureterectomy		0.69 (0.28–1.67)	0.406
Yes	135 (77.6)
No	39 (22.4)
Resection margin		1.14 (0.34–3.87)	0.835
Negative	95 (68.3)
Close or positive	44 (31.7)
Lymphovascular invasion		0.35 (0.15–0.82)	0.016
Negative	83 (62.4)
Positive	50 (37.6)
Perineural invasion		0.55 (0.20–1.52)	0.245
Negative	112 (84.2)
Positive	21 (15.8)
Histologic grade		0.86 (0.16–4.62)	0.856
Low	8 (5.3)
High	144 (94.7)
PD-L1		0 (0–0)	0.999
Negative	36 (83.7)
Positive	7 (16.3)
Concurrent chemotherapy		2.22 (1.02–4.85)	0.045	2.91 (1.11–7.65)	0.03
Yes	101 (58)
No	73 (42)
Interval between diagnosis to first recurrence		0.56 (0.27–1.17)	0.124
> 8 m	81 (48.8)
≤ 8 m	85 (51.2)
RT methods		0.53 (0.25–1.15)	0.107
2D/3D	61 (35.1)
IMRT	113 (64.9)
Radiation dose		0.38 (0.18–0.81)	0.011	2.67 (1.08–6.64)	0.034
≥ 45 Gy	81 (46.6)
< 45 Gy	93 (53.4)

Factors related with radiotherapy response were analyzed with logistic regression analysis

PD-L1 programmed death-ligand 1, IMRT intensity modulated radiotherapy, 2D 2-dimensional radiotherapy, 3D 3-dimensional radiotherapy