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. 2022 Mar 9;20:125. doi: 10.1186/s12951-022-01318-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Intracellular localization and biodistribution of the PEG-CZNPs. A Confocal microscopy analysis of human podocyte treated with FITC-labeled PEG-CZNPs after 0, 4, 8, 16, 24, 48, 72 and 96 h. The human podocytes were then double-stained with Mitotracker (orange) and Lysotracker (blue). B TEM images of human podocytes treated with PEG-CZNPs after 0, 24, and 48 h. Residual PEG-CZNPs were found to be distributed in the lysosomes (red arrow). C STEM images of PEG-CZNPs in the lysosome of human podocytes D EDS spectra of PEG-CZNPs in the lysosomes of human podocytes to confirm their atomic compositions; 67 at% Ce and 32 at% Zr