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Beneficial effects of PEG-CZNPs on cellular survival and apoptosis in HK-2 cell model of FD. A, B Analysis of apoptosis in HK-2 cells using a FACS assay C Immunoblotting of MAPK dependent intracellular signaling. D-F Quantitative real-time RT-PCR analysis of HES-1, MCP-1, caspase 4, Bax and Bcl-2 gene expression. Data values represent the mean ± SD; *P < 0.05, and **P < 0.01, versus control; #P < 0.05, and ##P < 0.01 versus siGLA knockdown alone
