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. 2022 Mar 9;20:28. doi: 10.1186/s12964-022-00835-1

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — ucMSC-Evs suppress PDGF-induced proliferation of rMCs. A proliferation of rMCs determined by EdU labeling; B viability of cells determined using a CTG kit; C portion of dead cells confirmed by EB fluorescence staining; D apoptosis of cells determined by Hoechst 33,258 staining; E, apoptosis rate of cells determined by flow cytometry; F, G mRNA (F) and protein (G) expression of Cyclin D2, PCNA, Bax and PUMA in cells determined by RT-qPCR and western blot analysis, respectively; H, total collagen concentration in rMCs determined by collagen kits; I, J, expression of fibronectin-1 and collagen IV in cells determined by RT-qPCR and immunofluorescence staining. Data were expressed as mean ± SD from at least three independent experiments. Data were analyzed by two-way ANOVA followed by Tukey’s multiple comparison test. **p < 0.01, ***p < 0.001 versus PBS group; ##p < 0.01, ###p < 0.001 versus 0 μg/mL group