Fig. 1.

Serial MRI changes of case 1. A & B MRI brain scan (axial FLAIR sequence) and cervical spine (sagittal T2 sequence) at the time of the diagnosis of MS. Note few periventricular brain lesions and ill-defined focal areas of T2 hyperintensity at C4, C5, and C6 levels. C, D, E MRI brain scan at the third relapse following Alemtuzumab therapy. Axial, sagittal, and coronal FLAIR sequences are shown here. Note bilateral large supratentorial lesions with ill-defined borders, mostly juxtacortical in location, with accompanying oedema. F Axial FLAIR image of the brain following mycophenolate therapy. Note the resolution of large juxtacortical lesions seen in C,D,E leaving a few periventricular residual lesions