Table 2.

Significantly dysregulated pathways predicted by pathway enrichment analysis

Pathway	Raw p	Impact	Hit metabolites
Purine metabolism	0.001	0.159	xanthine, phosphoribosyl formamidocarboxamide, adenylsuccinic acid, adenosine, inosine, adenine, hypoxanthine, guanine, 5-aminoimidazole ribonucleotide
Taurine and hypotaurine metabolism	0.020	0.353	taurine, 2-hydroxyethanesulfonate, pyruvic acid
Glycerophospholipid metabolism	0.026	0.204	citicoline, O-phosphoethanolamine, glycerylphosphorylethanolamine, CDP-ethanolamine
Nicotinate and nicotinamide metabolism	0.039	0.105	quinolinic acid, maleamate, NAD, pyruvic acid
Cysteine and methionine metabolism	0.081	0.172	5’-methylthioadenosine, S-adenosylhomocysteine, glutathione, pyruvic acid