Table 1.
Characteristics of participants according to α1-antitrypsin genotype
| Genotype | MM | SZ | ZZ |
|---|---|---|---|
| Women/men | 50,206/40,942 | 124/83 | 95/90 |
| Age, yrs | 57.8 ± 13.1 | 56.7 ± 13.3 | 54.8 ± 13.1† |
| Body mass index, kg/m2 | 26.2 ± 4.3 | 26.3 ± 4.7 | 26.2 ± 5.2 |
| Plasma α1-antitrypsin, µmol/L | 24.0 ± 4.1 | 10.4 ± 2.0‡ | 4.7 ± 4.8‡ |
| FEV1/FVC, % | 77.4 ± 15.9 | 76.5 ± 10.6 | 60.3 ± 19.3‡ |
| Smoking, no. (%) | |||
| Never smoker | 35,533 (40.6) | 84 (42.9) | 73 (41.4) |
| Ex smoker | 36,119 (41.3) | 82 (41.6) | 89 (51.7) |
| Current smoker | 15,861 (18.1) | 31 (15.8) | 12 (6.9)† |
| Chronic Obstructive Pulmonary Disease, no. (%) | 5,137 (5.7) | 25 (12.2)‡ | 100 (54.1)‡ |
| Antihypertensive medication, no. (%) | 17,898 (19.7) | 45 (22.0) | 41 (22.7) |
Values presented as mean ± SD or number (%). †P value < 0.01, ‡Pvalue < 0.001 on Student’s t-test or Pearson’s χ2 test versus MM genotype. FEV1 forced expiratory volume in 1 s. FVC forced vital capacity