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| Type II-Cas9 | Type V-Cas12 | Type VI-Cas13 | |
|---|---|---|---|
| Subtypes | Deactivated Cas9 (dCas9) | Cas12a (Cpf1) | Cas13a (C2c2) |
| Cas9 nickase (nCas9) | Cas12b (C2c1) | Cas13b | |
| Cas12f (Cas14) | |||
| Target (activator) | dsDNA | dsDNA | RNA |
| ssDNA | |||
| gRNA | crRNA + tracrRNA | crRNA | crRNA |
| Platforms | NASBACC48 | DETECTR54 | SHERLOCK58 |
| CRISDA49 | HOLMES43 | HUDSON-SHERLOCK44 | |
| CRISPR-Chip50 | CRISPR-hydrogel69 | CARMEN61 |
