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. 2022 Mar 9;20:123. doi: 10.1186/s12951-022-01339-3

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Characterization of sEV-CUR. a Representative TEM images of sEV and sEV-CUR, scale bar: 100 nm; b average particle diameter distribution of sEV and sEV-CUR was analyzed by a nano-flow cytometry; c Western blot analysis of CD63, TSG101, and GM130 from ADMSCs, sEV, and sEV-CUR. CD63 and TSG101: sEV surface marker; GM130: the Golgi marker; d Zeta potential of sEV and sEV-CUR (n = 12). N.S., not significant