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. 2022 Mar 9;20:123. doi: 10.1186/s12951-022-01339-3

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — sEV-CUR exert an enhanced anti-oxidative and anti-apoptosis ability. a, b Immunofluorescence staining and statistical analysis of oxidative stress related marker 8-OHdG in each group (n = 3), scale bar: 50 μm; c MDA level was evaluated in each group (n = 3); d ROS level in each group was detected after curcumin, sEV, or sEV-CUR treatment for 2 days (n = 3); e, f representative images and quantitative analysis of TUNEL staining analysis to detect chondrocyte apoptosis (Red) different groups, scale bar, 50 μm; g, h chondrocyte apoptotic degree in each group was detected and analyzed by flow cytometry assay (n = 3). *P < 0.05, **P < 0.01, ***P < 0.001