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BR105 shows pan-allele anti-hSIRPα binding. (A) Binding of BR105 to various human SIRPα variant (V1, V2 and V8) was determined by ELISA. (B) Bio-Layer Interferometry analysis of the binding kinetics of BR105 to SIRPα V1. (C) Binding of BR105 to cell-expressed SIRPα V1 (U937) and SIRPα V2 (THP-1) was determined by flow cytometry analysis. (D) BR105 bound to monocytes, macrophages and neutrophils. Data represent mean ± SEM; representative of n=3 is shown.
