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. 2022 Mar 7;10(3):e004054. doi: 10.1136/jitc-2021-004054

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.

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BR105 can be safely administered intravenously in non-human primates. BR105 was administered intravenously to cynomolgus monkeys at 15, 50, and 150 mg/kg (five males and five females for each group) one time per week for 4 weeks. Following the dosing period, two animals/sex per group were maintained for a 6-week recovery period. (A, B) Peripheral blood was collected for hematology during the pre-dose phase; on Days 2 and 16 of the dosing phase; and on Days 30 and 71 of the recovery period. (C) Serum concentration-time profiles of BR105 following intravenous repeat doses in cynomolgus monkeys (semi-logatithmic). Values are presented as mean ± SD.