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. 2022 Feb 21;13(10):2985–2991. doi: 10.1039/d1sc07190d

MIC values for laspartomycin C position 10 variants.

graphic file with name d1sc07190d-u1.jpg
Compound AA10 R MICa
1 mM Ca2+ 10 mM Ca2+
1 (LaspC) l-Ile graphic file with name d1sc07190d-u2.jpg 8 2
10 Gly graphic file with name d1sc07190d-u3.jpg >64 >64
11 l-Ala graphic file with name d1sc07190d-u4.jpg 64 8
12 l-Abu graphic file with name d1sc07190d-u5.jpg 32 8
13 l-Nval graphic file with name d1sc07190d-u6.jpg 16 4
14 l-Val graphic file with name d1sc07190d-u7.jpg 8 2
15 l-Phe graphic file with name d1sc07190d-u8.jpg 16 8
a

Minimum inhibitory concentration reported in μg mL−1 against MRSA USA 300 at the Ca2+ concentration indicated. All compounds tested in triplicate.