MIC values for laspartomycin C position 10 variants.
Compound | AA10 | R | MICa | |
---|---|---|---|---|
1 mM Ca2+ | 10 mM Ca2+ | |||
1 (LaspC) | l-Ile | 8 | 2 | |
10 | Gly | >64 | >64 | |
11 | l-Ala | 64 | 8 | |
12 | l-Abu | 32 | 8 | |
13 | l-Nval | 16 | 4 | |
14 | l-Val | 8 | 2 | |
15 | l-Phe | 16 | 8 |
Minimum inhibitory concentration reported in μg mL−1 against MRSA USA 300 at the Ca2+ concentration indicated. All compounds tested in triplicate.