Fig. 5.

MiR-5195-3p induced the regression of prostate tumorigenesis in vivo. A MiR-5195-3p expression in stable miR-5195-3p mimics or miR-NC overexpression PC-3 cells determined by quantitative real-time PCR. B Image of tumor xenografts in nude mice injected subcutaneously with miR-5195-3p-overexpressing PC-3 cells. C Tumor volume was measured every 5 days. D Changes in the tumor weight in mice after miR-5195-3p overexpression. E MiR-5195-3p expression in tumor tissue isolated from miR-5195-3p mimics and miR-NC groups of nude BALB/c mice. F Protein expression levels of Cyclin L1, CDK4, and Cyclin D1 expression were determined by western blot analysis. Data are presented as mean ± standard deviation. **p < 0.01, ***p < 0.001 compared with miR-NC