Table 12.
Effects of Glucomedix® on diastolic blood pressure in hypertensive rats induced by L-NAME
| Group/dose (mg/kg) | Time (days) | ||||
|---|---|---|---|---|---|
| 0 days | 7 days | 14 days | 21 days | 28 days | |
| NT | 75.0 ± 2.71 | 76.6 ± 1.62 | 76.4 ± 2.07 | 76.3 ± 2.81 | 75.4 ± 2.64 |
| LN | 79.9 ± 2.91 | 125.9 ± 1.86** | 121.0 ± 1.41 ** | 119.3 ± 1.11 ** | 125.1 ± 1.57 ** |
| LN + Enal 25 | 84.7 ± 0.76 * | 87.6 ± 1.40 *++ | 86.0 ± 1.29 *++ | 101.3 ± 0.95 **+ | 94.4 ± 2.37 **++ |
| LN + GM 250 | 86.6 ± 1.62* | 125.7 ± 2.21** | 125.4 ± 1.99 ** | 128.3 ± 0.76**+ | 117.7 ± 1.11 **+ |
| LN + GM 500 | 86.9 ± 1.77* | 91.0 ± 1.15*++ | 97.1 ± 1.07**++ | 108.7 ± 0.95**+ | 104.3 ± 0.76**++ |
| LN + GM 1000 | 78.9 ± 3.08 | 89.6 ± 1.51*++ | 87.6 ± 0.98 *++ | 102.0 ± 1.53**+ | 96.3 ± 1.11 **++ |
Values are expressed as mean ± SD. n = 7; NT = normotensive control; LN = L-NAME induced control; LN + Enal = Enalapril; LN + GM 250, LN + GM 500 and LN + GM 1000 = GlucoMedix at 250, 500 and 1000 mg/kg respectively. * p < 0.05, ** p < 0.001 compared to normotensive control group; +p < 0.05, ++p < 0.001 compared to L-NAME (LN) induced control group