Table 13.
Effects of Glucomedix® on mean blood pressure in hypertensive rats induced by L-NAME
| Group/dose (mg/kg) | Time (days) | ||||
|---|---|---|---|---|---|
| 0 days | 7 days | 14 days | 21 days | 28 days | |
| NT | 86.9 ± 1.59 | 87.7 ± 0.84 | 87.8 ± 1.20 | 87.7 ± 1.87 | 87.0 ± 1.79 |
| LN | 90.4 ± 2.12 | 134.7 ± 1.01** | 134.7 ± 0.80** | 136.6 ± 1.24** | 143.1 ± 1.19 ** |
| LN + Enal 25 | 94.0 ± 0.47 | 97.9 ± 1.17* | 97.6 ± 0.92*++ | 108.6 ± 0.76*++ | 101.9 ± 2.07 *++ |
| LN + GM 250 | 95.4 ± 1.29 | 135.6 ± 1.77** | 131.2 ± 2.23** | 132.1 ± 1.53**+ | 129.8 ± 0.84 **+ |
| LN + GM 500 | 96.3 ± 1.12 | 112.3 ± 1.26*+ | 112.7 ± 0.71*+ | 121.6 ± 0.89*+ | 115.4 ± 0.71 *+ |
| LN + GM 1000 | 91.3 ± 2.19 | 106.7 ± 2.55*++ | 108.1 ± 2.70*++ | 116.2 ± 1.07*++ | 105.4 ± 0.81 *++ |
Values are expressed as mean ± SD. n = 7; NT = normotensive control; LN = L-NAME induced control; LN + Enal = Enalapril; LN + GM 250, LN + GM 500 and LN + GM 1000 = GlucoMedix at 250, 500 and 1000 mg/kg respectively. * p < 0.05, ** p < 0.001 compared to normotensive control group; +p < 0.05, ++p < 0.001 compared to L-NAME (LN) induced control group