TABLE 2.

Relationship of KYN metabolites with other inflammatory parameters in COVID‐19 patient and control groups and total cases

Group	TRP	KYN	KYN:TRP ratio	KYNA	3OHKYN	QA	PA
N:L Ratio
Total	−0.339*	0.271*	0.412*	0.570*	0.393*	0.609*	0.521*
COVID‐19	−0.184	0.074	0.129	0.373*	0.384*	0.374*	0.185
Control	0.083	0.026	−0.018	0.023	0.303	0.116	0.211
LDH
Total	−0.069	0.470*	0.442*	0.510*	0.127	0.546*	0.567*
COVID‐19	0.260*	0.271*	0.029	0.034	0.016	0.009	0.250*
Control	0.007	0.068	0.165	0.116	0.044	0.027	−0.067
Procalcitonin
Total	−0.210*	0.316*	0.418*	0.368*	0.226*	0.446*	0.358*
COVID−19	−0.090	0.230	0.322*	0.274*	0.239*	0.324*	0.144
Control	−0.079	−0.110	0.089	−0.058	0.031	0.061	0.220
Troponin
Total	−0.290*	0.351*	0.447*	0.590*	0.237*	0.664*	0.431*
COVID‐19	−0.105	0.027	0.083	0.344*	0.244*	0.283*	−0.103
Control	−0.087	0.056	0.097	−0.136	−0.140	0.082	0.247
D‐Dimer
Total	−0.218*	0.334*	0.400*	0.536*	0.065	0.606*	0.573*
COVID‐19	0.118	−0.037	−0.182	0.069	−0.153	−0.013	0.104
Control	−0.181	−0.132	0.089	−0.101	−0.046	−0.100	0.086
Fibrinogen
Total	−0.156	0.240*	0.322*	0.469*	0.225*	0.602*	0.507*
COVID‐19	0.103	−0.139	−0.176	0.018	0.169	0.159	0.110
Control	0.242	−0.110	−0.208	0.132	0.057	−0.086	−0.113
CRP
Total	−0.291*	0.343*	0.475*	0.626*	0.215*	0.750*	0.530*
COVID‐19	−0.081	−0.089	−0.067	0.216	0.200	0.336	−0.004
Control	0.079	0.268	0.231	0.220	−0.152	0.259	−0.125
IL‐6
Total	−0.384*	0.442*	0.599*	0.498*	0.295*	0.682*	0.524*
COVID‐19	−0.158	0.295*	0.376*	0.144	0.268*	0.303*	0.089
Control	−0.160	0.033	0.234	−0.211	−0.018	0.047	0.126
Ferritin
Total	−0.185	0.503*	0.517*	0.630*	0.212*	0.655*	0.584*
COVID‐19	0.067	0.392*	0.305*	0.370*	0.216	0.288*	0.285*
Control	0.117	−0.090	−0.253	0.156	−0.239	−0.001	−0.183
TRP
Total		−0.024	−0.528*	−0.229*	−0.303*	−0.433*	−0.179
COVID‐19		0.187	−0.388*	−0.172	−0.285*	−0.317*	0.138
Control		0.047	−0.611*	0.492*	−0.019	−0.106	−0.126
KYN
Total			0.832*	0.615*	0.382*	0.631*	0.533*
COVID‐19			0.800*	0.503*	0.319*	0.481*	0.441*
Control			0.691*	0.357*	0.371*	0.566*	0.168
KYN:TRP ratio
Total				0.604*	0.432*	0.765*	0.545*
COVID‐19				0.512*	0.441*	0.608*	0.303*
Control				−0.075	0.295*	0.514*	0.212
KYNA
Total					0.485*	0.764*	0.518*
COVID‐19					0.631*	0.655*	0.250*
Control					−0.036	0.070	−0.017
3OHKYN
Total						0.475*	0.264*
COVID‐19						0.592*	0.140
Control						0.242	0.279
QA
Total							0.575*
COVID‐19							0.147
Control							0.159

Bold indicates statistically significant value (p < 0.05).