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. 2021 May 31;1:100031. doi: 10.1016/j.crpvbd.2021.100031

Table 2.

In vitro anti-T. cruzi (amastigotes, CA-I/72 strain) activity of DBAs (IC50), cytotoxicity in infected C2C12 cell line (CC50) and selectivity index (SI) in the time-course evaluation

DBA IC50, CC50 (μM) ± SD and SI
8 h
 12 h
 24 h
 48 h
IC50 CC50 SI IC50 CC50 SI IC50 CC50 SI IC50 CC50 SI
1 >100 12.20 ± 1.15 ND 76.78 ± 1.39 2.00 ± 0.42 0.02 37.53 ± 1.01 0.28 ± 0.04 0.007 14.61 ± 1.10 0.03 ± 0.02 0.002
2 >100 40.73 ± 1.07 ND >100 3.03 ± 0.79 ND >100 0.33 ± 0.41 ND >100 0.02 ± 0.03 ND
3 >100 29.81 ± 1.32 ND 63.30 ± 3.87 2.79 ± 0.30 0.04 62.08 ± 1.52 0.21 ± 0.13 0.003 3.72 ± 0.56 0.22 ± 0.17 0.05
4 >100 >100 ND >100 60.41 ± 1.11 ND >100 2.98 ± 0.24 ND 34.47 ± 0.94 0.66 ± 0.29 0.01
5 >100 93.29 ± 0.42 ND >100 10.55 ± 1.26 ND >100 0.30 ± 0.02 ND >100 0.20 ± 0.01 ND
CUR >100 60.34 ± 1.54 ND >100 9.95 ± 1.17 ND 51.65 ± 1.26 1.88 ± 0.17 0.03 2.25 ± 0.65 0.47 ± 0.09 0.20
BZ >10 >10 ND 6.85 ± 1.56 3.98 ± 0.31 0.58 5.97 ± 1.20 3.48 ± 0.70 0.58 1.54 ± 0.36 0.27 ± 0.07 0.17

Abbreviations: SI, selectivity index (values determined by CC50/IC50); BZ, benznidazole (positive control for Chagas disease); CUR, curcumin (reference curcuminoid); ND, not determined.