Table 3.
In vitro cytotoxicity activity (CC50) of DBAs in infected C2C12 cell line and selectivity index (SI) after 72 h
| Compound | CC50 (μM) ± SD of infected C2C12 cells |
|||||||
|---|---|---|---|---|---|---|---|---|
| Brazil strain |
CA-I/72 strain |
Sylvio X10/4 strain |
Sylvio X10/7 strain |
|||||
| CC50 | SI | CC50 | SI | CC50 | SI | CC50 | SI | |
| 1 | 7.32 ± 0.41 | 0.35 | 5.74 ± 1.95 | 1.22 | 3.80 ± 0.24 | 0.11 | 3.29 ± 1.00 | 0.28 |
| 2 | 5.15 ± 0.13 | 0.10 | 4.30 ± 1.22 | 0.24 | 2.54 ± 1.86 | 0.05 | 0.90 ± 1.20 | 1.87 |
| 3 | 1.73 ± 0.05 | 0.43 | 1.62 ± 0.22 | 1.07 | 1.25 ± 0.02 | 0.13 | 1.15 ± 0.29 | 0.23 |
| 4 | 0.09 ± 0.11 | ND | 0.60 ± 0.16 | 0.12 | 0.11 ± 0.10 | ND | 0.37 ± 0.14 | 0.01 |
| 5 | 12.38 ± 2.29 | 2.25 | 15.46 ± 1.25 | 0.45 | 11.79 ± 7.74 | 0.20 | 4.06 ± 2.31 | 0.16 |
| CUR | 2.36 ± 1.24 | 0.20 | 6.71 ± 0.70 | 2.47 | 1.91 ± 0.02 | 0.09 | 3.37 ± 1.33 | 0.29 |
| BZ | >10 | ND | >10 | ND | >10 | ND | >10 | ND |
Abbreviations: SI, selectivity index (values determined by CC50/IC50 from intracellular amastigotes assays of the different strains after 72 h incubation); BZ, benznidazole (positive control for Chagas disease); CUR, curcumin (reference curcuminoid); ND, not determined.