Table 4.
In vitro cytotoxicity activity (CC50) of DBAs in non-infected C2C12 and LLC-MK2 cell lines and selectivity index (SI) after 72 h
| DBA | CC50 ± SD (μM) |
SI |
||
|---|---|---|---|---|
| C2C12 | LLC-MK2 | C2C12 | LLC-MK2 | |
| 1 | 40.13 ± 1.25 | 16.57 ± 0.61 | 8.59 | 3.54 |
| 2 | 35.50 ± 0.50 | 31.39 ± 1.20 | 2.03 | 1.79 |
| 3 | 20.82 ± 0.67 | 11.51 ± 0.34 | 13.78 | 7.62 |
| 4 | 53.67 ± 1.26 | 50.10 ± 7.92 | 10.71 | 10.00 |
| 5 | 38.27 ± 1.69 | 38.12 ± 1.81 | 1.13 | 1.13 |
| CUR | 18.03 ± 0.42 | 32.49 ± 0.49 | 6.65 | 11.98 |
| BZ | 37.85 ± 1.54 | 167.50 ± 2.98 | 18.73 | 82.92 |
Abbreviations: SI, selectivity index (values determined by CC50/IC50 from intracellular amastigotes assay (72 h incubation, CA-I/72 strain)); BZ, benznidazole (positive control for Chagas disease); CUR, curcumin (reference curcuminoid).