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. 2022 Mar 4;15(3):dmm049205. doi: 10.1242/dmm.049205

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© 2022. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 2. — Tanc2 disruption alters body size and adipose tissue distribution. (A) Tanc2^−/− mice showed decreased body weight at all time points over the course of the analysis period, yet no difference in body weight gain was detected. (B-E) Body length (B), bone mineral content (BMC) (C) and bone mineral density (BMD) (D) were decreased, and BMC correlated positively with body weight (BW) (E). (F) BMD was not strongly predicted by BW. (G-I) Lean mass (G) and fat mass (H) were reduced, and there was a shift in body composition towards less fat in favour of lean mass, as indexed by decreased fat mass/lean mass ratio (I). Data are mean±s.d., males and females pooled. **P<0.01, ***P<0.001, +/+ versus −/− [linear mixed effect model (body weight), unpaired Student's t-test].