Fig. 6.

Dimensionality reduction of psychiatric and systemic variable effects of Tanc2 disruption. We performed a principal component analysis (PCA) to reduce the dimensionality of the variables related to Tanc2 disruption. (A,B) The contribution of variables to principal component (PC) 1 (A) and 2 (B). (C) Correlation circle showing clustering of variables in PC1 and 2. (D) Biplot depicting the variables and individual PC scores for the two genotypes, control (+/+) and Tanc2-disrupted mutants (−/−). Males and females were separated for PCA. (E) Individual plot of Ywhab^−/− mice and control PC scores with Tanc2^−/− mice PC scores and their respective controls. The coloured clouds denote animals from the same experimental group. AP, alkaline phosphatase; AT, aminotransferase; BMD, bone mineral density; carb, carbohydrate; HDL, high-density lipoprotein; MHC, metabolic home cage; OF, open field; PPI, prepulse inhibition; Min RER, minimum respiratory exchange ratio; TIBC, total iron-binding capacity.