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Effect of dose on mean ± SD concentrations of cyclic HPMPC (a) and cidofovir (b) in serum after intravenous infusion of cyclic HPMPC to HIV-infected patients. •, 1.5 mg/kg (n = 6); ○, 3.0 mg/kg (n = 6); ■, 5.0 mg/kg (n = 6); □, 7.5 mg/kg (n = 4).
