TABLE 1.
Pharmacokinetic parameters for cyclic HPMPC following intravenous administration to HIV-infected patientsa
| Dose (mg/kg) | No. of subjects | Wt (kg) | Cmax (μg/ml) | AUC0–∞ (μg · h/ml) | CL (ml/h/kg) | CLR (ml/h/kg) | CLCR (ml/h/kg) | Varea (ml/kg) | MRT (h) | VSS (ml/kg) | t1/2β (h) | % Dose excreted in 24 h | % Dose excreted as cidofovir |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1.5 | 6 | 84.6 (9.56) | 4.90 (1.03) | 7.11 (1.39) | 219 (50.2) | 113 (31.9) | 85.2 (25.8) | 337 (69.9) | 1.69 (0.11) | 368 (73.3) | 1.07 (0.08) | 62.2 (22.1) | 8.43 (1.84) |
| 3.0 | 6 | 78.7 (18.7) | 11.0 (2.33) | 16.6 (3.42) | 187 (33.7) | 145 (25.5) | 76.7 (9.10) | 315 (64.1) | 1.78 (0.16) | 331 (55.8) | 1.17 (0.125) | 79.8 (18.0) | 10.6 (3.45) |
| 5.0 | 6 | 78.1 (9.09) | 18.5 (5.48) | 27.3 (3.64) | 186 (27.0) | 138 (15.0) | 91.3 (9.62) | 264 (45.6) | 1.62 (0.113) | 301 (53.5) | 0.981 (0.074) | 74.9 (4.86) | 10.0 (1.59) |
| 7.5 | 4 | 71.4 (7.54) | 25.6 (8.75) | 39.7 (12.1) | 200 (46.6) | 133 (29.8) | 94.6 (11.5) | 326 (55.2) | 1.80 (0.100) | 357 (75.6) | 1.15 (0.138) | 66.9 (6.62) | 8.19 (1.06) |
| Mean | 22 | 78.8 (12.4) | 198 (39.6) | 132 (27.3) | 86.2 (16.3) | 309 (62.8) | 1.72 (0.123) | 338 (65.1) | 1.09 (0.123) | 71.3 (16.0) | 9.40 (2.33) |
a
CLCR, creatinine clearance; Varea, volume of distribution based on area; MRT, mean residence time; VSS, volume of distribution at steady state; t1/2β, elimination half-life; the other abbreviations are defined in the text. Values are given as means (SDs).