FIGURE 2.
Participation of α-MSH, End-1, NGF, and vitamin D in the DNA damage response to UV, which results in reduced DNA photoproducts by activating NER, oxidative DNA damage by upregulating BER and antioxidant genes, and apoptosis, by increasing Bcl2 levels, thereby maintaining melanocyte survival and genomic stability. BER, base excision repair; NER, nucleotide excision repair