TABLE 1.
Common paracrine factors derived from both keratinocytes and fibroblasts
| Paracrine factor | Melanocyte receptors | Signaling pathway | Effect on melanocyte |
|---|---|---|---|
| HGF | c-Met | MAPK/PI3K-Akt | Induction of proliferation, motility, and survival |
| SCF | c-kit | MAPK/PI3K-Akt | Increased proliferation and survival |
| Sema7a | Plexin C1 | LIMKII | Inhibition of cell attachment and dendricity |
| ß1-integrin | MAPK/FAK | Increased cell attachment and dendricity | |
| Sema4D | Plexin B1 | Shp2 non-tyrosine phosphatase | Inhibition of c-Met signaling |
| Increased growth and survival |