Tab. 4:
Some software tools available for physiologically-based kinetic modeling
| Model | Developer/associated organization | Availabilitya |
|---|---|---|
| MEGen, a model equation generator (EG) linked to a parameter database | CEFIC LRI29 | Free |
| RVIS – open access PBPK modelling platform | CEFIC LRI, George Loizou (HSE)30 | Free |
| MERLIN-Expo, total exposure assessment chain | Ciffroy et al., 2016,31 | Free |
| KNIME suite of tools | COSMOS Project (SEURAT-1)32, Sala Benito et al., 2017 | Free |
| High-throughput toxicokinetics (httk) | US EPA, Wang, 2010 | Free |
| PLETHEM (Population Lifecourse Exposure-To-Health-Effects Model Suite) | Scitovation33, Pendse et al., 2017 | Free |
| Berkeley Madonna | Berkeley Madonna34 | Commercial |
| MATLAB | MathWorks35 | Commercial |
| Simcyp’s Population-based Simulator | Certara36 | Commercial |
| Gastroplus/ADMET/PBPK PLUS | SimulationPlus37 | Commercial |
| Computational Systems Biology Software Suite (PKSim), tools for the molecular level (MoBi), the organismal level (PK-Sim) |
Open Systems Pharmacology38 | Commercial |
a
List of available models adapted from Paini et al. (2017)