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. Author manuscript; available in PMC: 2022 Mar 9.
Published in final edited form as: Nat Struct Mol Biol. 2022 Feb 14;29(2):162–171. doi: 10.1038/s41594-022-00723-9

Extended Data Fig. 7 |. Steric occlusion of A-site tRNA binding by oxazolidinone antibiotics.

Extended Data Fig. 7 |

Linezolid (LZD, yellow) and radezolid (RZD, green) prevent binding of A-site tRNAs (blue, from PDB: 7K00). Prominent steric clashes between the A-tRNA and LZD C-ring and RZD C/D-ring are highlighted. Structural overlays were performed by alignment of 23S rRNA nucleotides.