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. 2022 Feb 23;9:815320. doi: 10.3389/fmolb.2022.815320

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Copyright © 2022 Gu, Chen, Sun, Wang, Wang, Lin, Lei, Zhang, Lv, Jiang, Deng, Collman and Fu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Plasmalogens enhance synaptic plasticity in the hippocampus of aged mice. (A) Representative images showing the expression of synaptophysin (green) in the CA1 and DG region of mice hippocampus. (B–C) Graph showing quantification of the immunostaining of synaptophysin in the CA1 and DG region of murine hippocampus (n = 4 mice for each group), and values are presented as mean ± SEM. (D) Representative immunoblotting of synaptophysin levels and (E) graph showing quantification of synaptophysin levels. The quantification is a ratio of synaptophysin/β-tubulin levels (n = 3 mice per group), and values are presented as mean ± SD. Asterisks indicate statistical significances compared to Aged control by one-way ANOVA; significance (*p < 0.05; **p < 0.01), scale bars, 50 μm.