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. Author manuscript; available in PMC: 2022 May 1.
Published in final edited form as: Mol Cell Endocrinol. 2021 Feb 13;527:111208. doi: 10.1016/j.mce.2021.111208

Fig. 3. Role of KISS1 in oocyte maturation.

Fig. 3.

48h after PMSG treatment, cumulus oocyte complex (COCs) were isolated from 4-wk-old wildtype and Erβnull rats and cultured in BO-IVM in presence or absence of 1nM of rat kisspeptin 10 (KP-10) for 20h. Approximately 55% of wildtype (A and C) and only 35% of Erβnull oocytes achieved meiotic maturation (MII) in BO-IVM culture (control) (D and F). Remarkably, addition of KP-10 to BO-IVM increased the in vitro maturation to 78% of wildtype (B and C) and 56% of Erβnull oocytes (E and F). Each treatment group contained at least 25 oocytes at each time point and repeated three times. Cont, Control.