Table 1.

Some of the FDA-approved MAD that can be applied to improve mild to moderate obstructive sleep apnea in patients 18 years and older.

Technical data of the available MADs
MAD	EMA	Narval	Pantera	NOA	Somnodent avant	Somnodent dorsal wings	Micro2	Herbst	Dream TAP	Orthoapnea classic
Coupling mechanism	Lateral superior-anterior to inferior-posterior	Lateral superior-anterior to inferior-posterior	Lateral superior-anterior to inferior-posterior	Lateral superior-posterior to inferior-posterior		Lateral superior-posterior to inferior-posterior	Lateral superior-posterior to inferior-posterior	Lateral superior-posterior to inferior-anterior	Anterior superior and inferior	Anterior superior and inferior
Coupling element	Lateral Straps	Lateral Straps	Lateral Straps	Cam/Follower	Anterior strap	Dorsal wings	Dorsal wings	Fixed rod	Anterior hook	Anterior rod
Titration mechanism	Diferent lenths of strips	Diferent lenths of strips	Diferent lenths of strips		Diferent lenths of anterior strip	Screw on lateral wings	Different lower splints	Screw on rod	Different lower splints	Screw on anterior rod
Titration protocol	"9 different lengths allow for 1 mm advancement of the mandible"	Different lengths	Different lengths	Customized titration	Initial set of 10 straps (+1mm) provided	One 360º turn of the screw is 0.4 mm / 6.0mm protrusion range	Customized titration	Range of advancement (8mm	One 360° turn of the srew is 0.5 mm / 15mm protrusion range	From-3mm to +7mm total range of screw 10mm
Material	Thermoformed splints	3D printed nylon appliance	3D printed nylon appliance	3D printed nylon appliance		Acrylic splint	Crystal-clear acrylic	Acrylic splint	Thermoformed splints	Thermoformed dual Laminate Splints
Fabrication	Tradicional laboratories	CAD/CAM-printed 3D	CAD/CAM-printed 3D	CAD/CAM-printed 3D	CAD/CAM-printed 3D	Tradicional laboratories	CAD/CAM-milled	Tradicional laboratories	Tradicional laboratories	Tradicional laboratories