TABLE 2.
Pathogenicity of the different thogotovirus isolates in C57BL/6 micea
| Genus | Isolate | Replication | Lethal dose |
|---|---|---|---|
| THOV-like | JOSV | Yes | >105 pfu (LD50) |
| HI-Kamigano25 | Yes | >105 pfu (LD50) | |
| Ken-IIA | Yes | 1 pfu (LD100) | |
| PoTi503 | Yes | >105 pfu (LD50) | |
| SiAr/126/72 | Yes | 1 pfu (LD100) | |
| DHOV-like | OzV | No | >105 pfu (LD50) |
| BRBV-KS | No | >105 pfu (LD50) | |
| India/1313/61 | Yes | 1 pfu (LD100) | |
| BKNV | Yes | 1 pfu (LD100) | |
| PoTi461 | Yes | 1 pfu (LD100) |
a
LD, lethal dose, infectious dose in plaque forming units (pfu) when 50% or 100% of i.p. infected animals were killed due to severe disease symptoms or their body weight loss reaching 25%.