TABLE 1.
Amino acid conservation in PA-X and PA proteins
| Amino acid change | Amino acid(s) (%)a |
|
|---|---|---|
| Human sequences (n = 279) | Avian sequences (n = 2,264) | |
| L16P | L (99.63), P (0.36) | L (100) |
| N33S | N (100) | N (99.92), D (0.04), S (0.04) |
| K34E | K (100) | K (99.54), R (0.4), T (0.04) |
| E43K | E (100) | E (99.92), G (0.04), D (0.04) |
| F76L | F (100) | F (99.92), C (0.04), Y (0.04) |
| E101G | E (66.18), D (31.29), N (1.8), G (0.36), V (0.36) | E (66.11), D (36.42), N (13.73), G (0.83), S (0.22), V (0.08) |
| P107S | P (100) | P (100) |
| D111N | D (100) | D (99.92), G (0.04), Y (0.04) |
| R125K | R (100) | R (99.96), K (0.04) |
| L132P | L (94. 6), M (5.4) | L (99.5), M (0.45), I (0.04) |
| H146Y | H (100) | H (100) |
| I147T | I (100) | I (99.88), M (0.08), T (0.04) |
| E153V | E (100) | E (99.96), G (0.04) |
| R170G | R (100) | R (99.96), G (0.04) |
| L187P | L (100) | L (99.76), I (0.24) |
| F191L | F (100) | F (100) |
| E196Gb | E (100) | E (99.88), K (0.04), V (0.04), D (0.04) |
a
Amino acid residues in A/Viet Nam/1203/2004 H5N1 PA-X WT are underlined. The frequencies of IAV H5N1 PA-X proteins containing the indicated residue are shown.
b
The E196G amino acid substitution does not change the A/Viet Nam/1203/2004 H5N1 PA amino acid sequence.