Skip to main content
. 2022 Mar 9;96(5):e00408-21. doi: 10.1128/JVI.00408-21

TABLE 1.

Amino acid conservation in PA-X and PA proteins

Amino acid change Amino acid(s) (%)a
Human sequences (n = 279) Avian sequences (n = 2,264)
L16P L (99.63), P (0.36) L (100)
N33S N (100) N (99.92), D (0.04), S (0.04)
K34E K (100) K (99.54), R (0.4), T (0.04)
E43K E (100) E (99.92), G (0.04), D (0.04)
F76L F (100) F (99.92), C (0.04), Y (0.04)
E101G E (66.18), D (31.29), N (1.8), G (0.36), V (0.36) E (66.11), D (36.42), N (13.73), G (0.83), S (0.22), V (0.08)
P107S P (100) P (100)
D111N D (100) D (99.92), G (0.04), Y (0.04)
R125K R (100) R (99.96), K (0.04)
L132P L (94. 6), M (5.4) L (99.5), M (0.45), I (0.04)
H146Y H (100) H (100)
I147T I (100) I (99.88), M (0.08), T (0.04)
E153V E (100) E (99.96), G (0.04)
R170G R (100) R (99.96), G (0.04)
L187P L (100) L (99.76), I (0.24)
F191L F (100) F (100)
E196Gb E (100) E (99.88), K (0.04), V (0.04), D (0.04)
a

Amino acid residues in A/Viet Nam/1203/2004 H5N1 PA-X WT are underlined. The frequencies of IAV H5N1 PA-X proteins containing the indicated residue are shown.

b

The E196G amino acid substitution does not change the A/Viet Nam/1203/2004 H5N1 PA amino acid sequence.