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Study design and schema of the structural changes. ADAMTS-4, a disintegrin and metalloproteinase with thrombospondin motif 4; COL2, type II collagen; DDH, developmental dysplasia of the hip; ECM, extracellular matrix; FAI, femoroacetabular impingement; IL-1β, interleukin 1β; MMP-13, matrix metalloproteinase 13; NITEGE, aggrecan antibody to C-terminal neoepitope; OA, osteoarthritis; OARSI, Osteoarthritis Research Society International.
