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. 2022 Mar 2;9(2):ENEURO.0264-21.2021. doi: 10.1523/ENEURO.0264-21.2021

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Copyright © 2022 Lakunina et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 6. — Contributions of distinct inhibitory neuron types to auditory signal detection. A, Inactivation of PV⁺ cells during the signal detection task. Laser was presented for a random 25% of trials each session. B, Example psychometric curve from one PV::ArchT mouse (trials pooled across multiple sessions). Inactivation of auditory cortical PV⁺ cells decreased the probability of the mouse reporting hearing the signal when it was present, though false alarm rate was unaffected. Error bars show 95% confidence intervals. C, Inactivating auditory cortical PV⁺ cells during the signal detection task significantly reduced sensitivity to the signal (p = 0.0046, Wilcoxon signed-rank test; N = 13 mice). D, Inactivating auditory cortical PV⁺ cells during the signal detection task significantly reduced the hit rate (p = 0.033, Wilcoxon signed-rank test). E, Inactivating auditory cortical PV⁺ cells during the signal detection task did not significantly affect the false alarm rate (p = 0.861, Wilcoxon signed-rank test). F, The effect of inactivating auditory cortical PV⁺ cells (No PV) on d′ was not correlated with the effect of visual distraction (control) on d′ (p = 0.609, r = 0.157; linear correlation coefficient). G, The effect of inactivating auditory cortical PV⁺ cells on hit rate was not correlated with the effect of visual distraction on hit rate (p = 0.657, r = –0.136; linear correlation coefficient). H, The effect of inactivating auditory cortical PV⁺ cells on false alarm rate was not correlated with the effect of visual distraction on false alarm rate (p = 0.981, r = –0.0073; linear correlation coefficient). I, Inactivation of SOM⁺ cells during the signal detection task. Laser was presented for a random 25% of trials each session. J, Like B, but for one SOM::ArchT mouse. Inactivation of auditory cortical SOM⁺ cells reduced the probability of the mouse reporting hearing the signal when it was present, though false alarm rate was unaffected. K, Inactivating auditory cortical SOM⁺ cells during the signal detection task significantly reduced sensitivity to the signal (p = 0.0051, Wilcoxon signed-rank test; N = 10 mice). L, Inactivating auditory cortical SOM⁺ cells during the signal detection task significantly reduced the hit rate (p = 0.0051, Wilcoxon signed-rank test). M, Inactivating auditory cortical SOM⁺ cells during the signal detection task did not significantly affect the false alarm rate (p = 0.878, Wilcoxon signed-rank test). N, The effect of inactivating auditory cortical SOM⁺ cells (No SOM) on d′ was not correlated with the effect of visual distraction (control) on d′ (p = 0.546, r = 0.218; linear correlation coefficient). O, The effect of inactivating auditory cortical SOM⁺ cells on hit rate was correlated with the effect of visual distraction on hit rate (p = 0.0494, r = 0.633; linear correlation coefficient). P, The effect of inactivating auditory cortical SOM⁺ cells on false alarm rate was not correlated with the effect of visual distraction on false alarm rate (p = 0.0725, r = 0.590; linear correlation coefficient).