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. 2022 Mar 4;3(1):e120. doi: 10.1002/mco2.120

FIGURE 7.

FIGURE 7

SHP2 promotes the formation of neutrophil extracellular traps (NETs) through the ERK5 pathway. (A) Heat map image of microarray analysis of RNA from human neutrophils (n = 3/group). (B) The mRNA expression levels of representative MAPK family genes in neutrophils. (C) The mRNA expression levels of MAPK7 in neutrophils in different time limits. (D) Quantification of dsDNA in neutrophils. (E) Representative immunofluorescence images staining for MPO (green), NE (red), and DAPI (blue) of neutrophils, scale bar = 30 μm. (F) The protein expression of MPO in neutrophils, tested by ELISA. (G) Quantification of dsDNA in neutrophils. (H) Phenotypic presentation of back skin sections of sham‐ or IMQ or/and AX‐15836‐treated mice, scale bar = 5 mm. (I) The H&E staining of back skin sections of sham‐ or IMQ or/and AX‐15836‐treated mice, scale bar = 50 μm. (J) The epidermal thickness of mice dorsal skin. (K) Clinical scores of mice dorsal skin