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. 2021 Nov 24;205(5):520–528. doi: 10.1164/rccm.202106-1350OC

Figure 2.

Figure 2.

Association of ICU versus ward admission with in-hospital mortality among patients with sepsis and acute respiratory failure (ARF): primary and sensitivity analyses. Among high-acuity patients with sepsis who did not require mechanical ventilation or vasopressors in the emergency department, admission to the ICU was associated with 48% increased odds of in-hospital mortality (odds ratio, 1.48; 95% confidence interval, 1.13–1.88; P = 0.004). Among high-acuity patients with ARF who did not require mechanical ventilation or vasopressors in the emergency department, admission to the ICU was associated with 25% decreased odds of in-hospital mortality (odds ratio, 0.75; 95% confidence interval, 0.57–0.96; P = 0.04). Overall, the directionality of sensitivity analyses results are consistent with the primary results throughout. Of note, restricting to patients who only met criteria for a single clinical cohort (sepsis only or ARF only) amplified the divergent results for each cohort further away from the null. *P < 0.05. ED = emergency department; LOS = length of stay; SDU = step-down unit.