Table 3. Factors associated with changes in ShTAL1 IgE response over the study period.
| Factor | ShTAL1-specific IgE (Responder vs. non-responder) | |||
|---|---|---|---|---|
| cOR (95% CI) | P-value of interaction | aOR (95% CI) | Wald’s P-value | |
| S.haematobium. Infection * Treatment | ||||
| S. h. positive * Baseline | 1.74 (0.40–7.49) | 0.458 | - | - |
| S. h. negative * Baseline | 1.00 (0.00) | - | - | - |
| S. h. positive * Follow-up | 13.33 (1.58–112.01) | 0.017 | 6.16 (0.71–53.59) | 0.099 |
| S. h. negative * Follow-up | 3.81 (1.84–7.89) | <0.001 | 5.38 (2.48–11.64) | <0.001 |
| STH Infection status | ||||
| Negative | 1 | - | 1 | - |
| Positive | 1.00 (0.00) | 1.00 | 3.94 (0.57–27.14) | 0.16 |
| Age (years) | ||||
| 6–11 | 1 | - | 1 | - |
| 12–14 | 9.64 (2.09–44.51) | 0.004 | 22.34 (2.77–180.14) | 0.004 |
| ≥ 15 | 14.26 (3.10–65.51) | 0.001 | 51.82 (6.44–417.17) | <0.001 |
| Gender | ||||
| Male | 1 | - | 1 | |
| Female | 0.53 (0.22–1.28) | 0.16 | 0.51 (0.17–1.52) | 0.225 |
| P. falciparum infection status | ||||
| Negative | 1 | - | 1 | - |
| Positive | 4.66 (1.69–12.79) | 0.003 | 2.14 (0.98–4.69) | 0.058 |
The Generalized Estimating Equation was used in determining the association of factors with ShTAL1 IgE response frequencies at baseline and at Follow-up (i.e. 7 weeks post-PZQ treatment). A product term was employed to assess the combined effect of S. haematobium infection status and treatment on ShTAL1 IgE positivity. cOR = crude Odds Ratio; aOR = adjusted Odds ratio; STH = soil-transmitted helminths comprising Ascaris lumbircoides, and Trichuris trichiura; ShTAL1 = S. haematobium-specific tegumental allergen-like protein 1. Significant values are in boldface.