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. 2022 Mar 9;17(3):e0264085. doi: 10.1371/journal.pone.0264085

Table 2. Participant preference and favorability rating* for self-collected saliva and anterior nasal swabs by location, reported demographics, symptoms and underlying medical history, Grady Memorial Hospital, Atlanta, GA, August–October 2020.

Preference Ease/Comfort ratingb
Saliva ANS None Saliva ANS
Favorable Unfavorable Favorable Unfavorable
Overall n = 1082 (100%)a 525 (48.5) 462 (42.7) 49 (4.5) 843 (80.4) 205 (19.6) 821 (77.2) 242 (22.8)
Demographics n (row %) p-value n (col %) p-value n (col %) p-value
Sex c
Male 269 (50.3) 234 (43.7) 32 (6.0) 0.15 438 (52.1) 104 (50.7) 0.72 432 (52.7) 120 (49.8) 0.42
Female 255 (51.2) 226 (45.4) 17 (3.4) 402 (47.9) 101 (49.3) 387 (47.3) 121 (50.2)
Age group, years
18–29 82 (58.2) 52 (36.9) 7 (5.0) 0.06 113 (13.4) 30 (14.6) 0.58 113 (13.8) 31 (12.8) 0.94
30–44 117 (54.2) 95 (44.0) 4 (1.9) 181 (21.5) 37 (18.0) 171 (20.8) 50 (20.7)
45–59 184 (46.9) 189 (48.2) 19 (4.8) 312 (37.0) 84 (41.0) 305 (37.1) 95 (39.3)
60+ 142 (49.5) 126 (43.9) 19 (6.6) 237 (28.1) 54 (26.3) 232 (28.3) 66 (27.3)
Race/Ethnicity
Black, non-Hispanic 436 (51.6) 368 (43.6) 41 (4.9) 0.15 694 (82.3) 157 (76.6) 0.18 668 (81.4) 196 (81.0) 0.92
Hispanic/Latino 36 (53.7) 26 (38.8) 5 (7.5) 54 (6.4) 16 (7.8) 52 (6.3) 18 (7.4)
Other/Refused/Unkd 17 (36.2) 29 (61.7) 1 (2.1) 39 (4.6) 10 (4.9) 39 (4.8) 10 (4.1)
White, non-Hispanic 36 (46.8) 39 (50.6) 2 (2.6) 56 (6.6) 22 (10.7) 62 (7.6) 18 (7.4)
Symptoms 0.69
None 178 (49.2) 162 (44.8) 22 (6.1) 0.23 316 (37.5) 57 (27.8) <0.01 292 (35.6) 84 (34.7)
Any symptom within 14 days 41 (47.1) 45(51.7) 1 (1.1) 73 (8.7) 13 (6.3) 70 (8.5) 17 (7.0)
Any current symptom 306 (52.1) 255 (43.4) 26 (4.4) 454 (53.9) 135 (65.9) 459 (55.9) 141 (58.3)
Nausea within 14 days
    Yes 125 (53.2) 98 (41.7) 12 (5.1) 0.59 175 (20.8) 60 (29.3) <0.01 173 (21.1) 67 (27.7) 0.03
    No 400 (49.9) 364 (45.4) 37 (4.6) 668 (79.2) 145 (70.7) 648 (78.9) 175 (72.3)
Cough within 14 days
    Yes 217 (51.5) 186 (44.2) 18 (4.3) 0.80 324 (38.4) 99 (48.3) <0.01 320 (39.0) 110 (45.5) 0.07
    No 308 (50.0) 276 (44.9) 31 (5.0) 519 (61.6) 106 (51.7) 501 (61.0) 132 (54.5)
Shortness of breath within 14 days
    Yes 224 (52.2) 190 (44.3) 15 (3.5) 0.26 332 (39.4) 101 (49.3) <0.01 331 (40.3) 109 (45.0) 0.19
    No 301 (49.6) 272 (44.8) 34 (5.6) 511 (60.6) 104 (50.7) 490 (59.7) 133 (55.0)
Medical history
Lung disease e
    Yes 136 (50.9) 121 (45.3) 10 (3.7) 0.68 200 (23.7) 68 (33.2) <0.01 196 (23.9) 76 (31.4) 0.02
    No 389 (50.6) 341 (44.3) 39 (5.1) 643 (76.3) 137 (66.8) 625 (76.1) 166 (68.6)
CKDf
    Yes 32 (45.7) 37 (52.9) 1 (1.4) 0.20 53 (6.4) 20 (9.9) 0.08 58 (7.2) 17 (7.1) 0.97
    No 489 (51.1) 421 (44.0) 47 (4.9) 781 (93.6) 183 (90.1) 753 (92.8) 223 (92.9)
Immunocompromisedg
    Yes 56 (64.4) 29 (33.3) 2 (2.3) 0.03 66 (7.9) 22 (11.1) 0.15 63 (7.7) 26 (11.0) 0.11
    No 464 (49.5) 426 (45.5) 47 (5.0) 771 (92.1) 177 (88.9) 752 (92.3) 210 (89.0)
Neurological d/oh, i
    Yes 42 (40.4) 58 (55.8) 4 (3.8) 0.05 83 (9.9) 22 (10.9) 0.68 85 (10.4) 22 (9.2) 0.58
    No 481 (52.0) 399 (43.1) 45 (4.9) 754 (90.1) 180 (89.1) 730 (89.6) 217 (90.8)
Dexterity Impairmentj
    Yes 7 (35.0) 12 (60.0) 1 (5.0) 0.35 16 (1.9) 5 (2.4) 0.62 18 (2.2) 3 (1.2) 0.35
    No 518 (51.0) 450 (44.3) 48 (4.7) 827 (98.1) 200 (97.6) 803 (97.8) 239 (98.8)
Location
Emergency Department (n = 866) 420 (50.6) 375 (45.2) 35 (4.2) 0.48 658 (78.1) 180 (87.8) <0.01 651 (79.3) 198 (81.8) 0.54
Pre-op Screening Clinic (n = 201) 100 (51.8) 80 (41.5) 13 (6.7) 170 (20.2) 25 (12.2) 157 (19.1) 42 (17.4)
Labor & Delivery (n = 15) 5 (38.5) 7 (53.8) 1 (7.7) 15 (1.8) 0 13 (1.6) 2 (0.8)

Abbreviations: ANS = Anterior nasal swab; Unk = Unknown; COPD = Chronic obstructive pulmonary disease; CKD = Chronic kidney disease; D/o = disorder; Pre-op = Pre-operative.

a There was a total of 1,036 participants who indicated a preference (46 missing), 1,048 participants who rated saliva collection (34 missing), and 1,063 participants who rated ANS collection (19 missing).

b An unfavorable rating was defined as at least one negative rating by a participant from the categories of very uncomfortable/uncomfortable or very difficult/difficult.

c Sex data missing from 3 participants who indicated a preference, and 3 participants who provide a saliva and ANS favorability ratings.

d This category includes persons of all other races, those who did not provide race/ethnicity data, and those for whom race/ethnicity data are otherwise unavailable.

e Lung disease includes COPD/emphysema and asthma.

f CKD status missing from 9 participants who indicated a preference, 11 participants who provided a saliva favorability rating, and 2 participants who provided an ANS favorability rating.

g Immunocompromised status missing for 12 participants who indicated a preference, 6 participants who provided saliva and ANS favorability ratings.

h Neurological d/o was defined as any self-reported neurological disorder, including seizure d/o such as epilepsy, Alzheimer’s, dementia, traumatic brain injury, and stroke/CVA.

I Neurological status was missing from 7 participants who indicted a preference, 6 participants who provided a saliva favorability rating, and 3 participants who provided an ANS favorability rating.

j Medical conditions that may affect dexterity were defined as: Arthritis (including osteoarthritis and unspecified type), multiple sclerosis, cerebral palsy, and carpal tunnel syndrome.