Table 2. Individual SARS-CoV-2 spike mutations for which data are available in CoV-RDB.
| Mutations | References | Results |
|---|---|---|
| Receptor-binding domain (RBD) | ||
| E484K | 45 | 832 |
| N501Y | 37 | 954 |
| K417N | 27 | 667 |
| L452R | 22 | 383 |
| N439K | 21 | 299 |
| S477N | 21 | 340 |
| Y453F | 17 | 291 |
| F490S | 15 | 149 |
| E484Q | 15 | 224 |
| G446V | 15 | 147 |
| A475V | 12 | 186 |
| N440K | 9 | 192 |
| T478K | 9 | 128 |
| Other mutations | 43 | 6658 |
| N-terminal domain (NTD) | ||
| Δ69/70 | 13 | 308 |
| Δ242 | 6 | 172 |
| L18F | 7 | 136 |
| D215G | 4 | 126 |
| R246I | 4 | 116 |
| D80A | 3 | 114 |
| Δ144 | 4 | 113 |
| Other mutations | 23 | 856 |
| C-terminal domain of S1 (CTD) | ||
| P681H | 8 | 130 |
| A570D | 4 | 88 |
| P681R | 2 | 29 |
| H655Y | 3 | 32 |
| Other mutations | 6 | 148 |
| S2 | ||
| A701V | 3 | 113 |
| S982A | 4 | 93 |
| D1118H | 4 | 88 |
| T716I | 4 | 87 |
| D936Y | 3 | 60 |
| Other mutations | 14 | 688 |
The most commonly studied mutation combinations that are not VOCs or VOIs included K417N+E484K+N501Y (n = 25 studies; 975 results), E484K+N501Y (n = 5 studies; 189 results), Δ69/70+N501Y (n = 8 studies; 158 results), Δ69/70+Y453F (n = 3 studies; 77 results), L452R+E484Q+P681R (n = 3 studies; 55 results) K417N+N501Y (n = 2 studies; 75 results), K417N+E484K (n = 2 studies; 75 results), and L452R+E484Q (n = 8 studies; 129 results).