Table 1.

Regression Models Predicting Age-18 Levels of Inflammation Biomarkers from Depression Risk Scores Calculated at Age 12.

Inflammation Biomarker	Model	N	Coefficient	95% CI	p
CRP level (mg/L)	1	1,026	2.52	0.83 – 4.21	0.004
	2	981	0.32	−1.76 – 2.41	0.760
IL-6 level (pg/mL)	1	1,034	0.13	−0.43 – 0.70	0.646
	2	989	−0.10	−0.85 – 0.65	0.786
suPAR level (ng/mL)	1	1,039	3.95	2.87 – 5.03	<0.001
	2	994	1.70	0.46 – 2.95	0.007

Note. CI = confidence interval; CRP = C-reactive protein; IL-6 = interleukin-6; suPAR = soluble urokinase plasminogen activator receptor. Model 1 is adjusted for familial clustering only. Model 2 is adjusted for familial clustering, body mass index, body temperature, smoking, sex, and prior depression. Statistically significant (p < 0.05) associations are shown in bold.