Table 2.

Regression Models Predicting Age-18 Levels of Inflammation Biomarkers from Age-12 Depression Risk Group Membership (low- versus high-risk).

Inflammation Biomarker	Model	Coefficient	95% CI	p
CRP level (mg/L)	1	0.34	−0.03 – 0.70	0.070
	2	0.29	−0.06 – 0.65	0.103
IL-6 level (pg/mL)	1	−0.01	−0.16 – 0.14	0.887
	2	0.02	−0.14 – 0.18	0.815
suPAR level (ng/mL)	1	0.51	0.28 – 0.75	<0.001
	2	0.41	0.18 – 0.64	<0.001

Note. CI = confidence interval; CRP = C-reactive protein; IL-6 = interleukin-6; suPAR = soluble urokinase plasminogen activator receptor. Model 1 is adjusted for familial clustering only (N = 287). Model 2 is adjusted for familial clustering, body mass index, body temperature, smoking, and prior depression (N = 273). Low-risk group defined as a risk score for age-18 MDD ≤ 10th percentile; high-risk group defined as a risk score for age-18 MDD ≥ 90th percentile. Statistically significant (p < 0.05) associations are shown in bold.