Table 3.
Effect of Leptin on the Relationship of Week 96 Body Composition With Homeostatic Model Assessment of Insulin Resistance and High-Sensitivity C-Reactive Protein (Mediation Model Approach)
| Effect of Leptin on the Relationship of Week 96 Body Composition With HOMA-IR (Mediation Model Approach) | ||||||
|---|---|---|---|---|---|---|
| Model 1 | Model 2 | Model 3 | ||||
| Exposure: Body Composition Outcome: HOMA-IR |
Exposure: Body Composition Outcome: Leptin |
Exposure: Body Composition Potential Mediator: Leptin Outcome: HOMA-IR |
||||
| Week 96 Body Composition Parameter | Adjusted Week 96 HOMA-IR (95% CI) | P Value | Adjusted Week 96 Leptin (95% CI) | P Value | Adjusted Week 96 HOMA-IR (95% CI) | P Value |
| Trunk fat (kg) | 0.35 (.24–.46) | <.001 | 0.67 (.59–.76) | <.001 | 0.01 (–.15 to .17) | .92 |
| Limb fat (kg) | 0.30 (.16–.44) | <.001 | 0.70 (.59–.81) | <.001 | –0.12 (–.29 to .05) | .16 |
| SAT (cm2) | 0.01 (.009–.014) | <.001 | 0.02 (.02–.02) | <.001 | –0.001 (–.006 to .004) | .73 |
| VAT (cm2) | 0.017 (.009–.026) | <.001 | 0.03 (.03–.04) | <.001 | 0.000 (–.009 to .009) | .95 |
| Effect of Leptin on the Relationship of Week 96 Body Composition With hsCRP (Mediation Model Approach) | ||||||
| Model 1 | Model 2 | Model 3 | ||||
| Exposure: Body Composition Outcome: hsCRP |
Exposure: Body Composition Outcome: Leptin |
Exposure: Body Composition Potential Mediator: Leptin Outcome: hsCRP |
||||
| Adjusted Week 96 hsCRP (95% CI) |
P Value | Adjusted Week 96 Leptin (95% CI) | P Value | Adjusted Week 96 hsCRP (95% CI) |
P Value | |
| Trunk fat (kg) | 0.36 (.19–.54) | <.001 | 0.67 (.59–.76) | <.001 | 0.25 (–.00 to .51) | .05 |
| Limb fat (kg) | 0.26 (.05–.47) | .02 | 0.70 (.59–.81) | <.001 | 0.01 (–.27 to .28) | .97 |
| SAT (cm2) | 0.01 (.003–.016) | .002 | 0.02 (.02–.02) | <.001 | 0.004 (–.004 to .012) | .34 |
| VAT (cm2) | 0.024 (.012–.037) | <.001 | 0.03 (.03–.04) | <.001 | 0.017 (.003–.031) | .02 |
Rows shown in bold fulfill criteria for leptin mediation of the relationship between the body composition parameter and HOMA-IR or hsCRP.
Model 1: Week 96 level (log10) of HOMA-IR or hsCRP for every 10 units higher in body composition parameter, adjusted for age, sex, race, BMI, and pretreatment CD4+ T-cell count and HIV-1 RNA.
Model 2: Week 96 level (log10) of leptin for every 10 units higher in body composition adjusted for age, sex, race, BMI, and pretreatment CD4+ T-cell count and human immunodeficiency virus type 1 RNA.
Model 3: Model 1 further adjusted for week 96 leptin.
Abbreviations: CI, confidence interval; HOMA-IR, homeostatic model assessment of insulin resistance; hsCRP, high-sensitivity C-reactive protein; SAT, subcutaneous adipose tissue; VAT, visceral adipose tissue.