Table 3:

Echocardiographic changes over time between patients with Barlow’s disease with mitral regurgitation grade I/II versus mitral regurgitation grade III/IV (at the time of the first echocardiography)

Parameter	MR grade I/II (N = 40)	MR grade III/IV (N = 24)	P-value between groups	P-value group-time interaction
LVEDD (mm), mean ± SD				0.94
First TTE	54 ± 7	56 ± 6	0.26
Last TTE	57 ± 7*	56 ± 6	0.64
LVESD (mm), mean ± SD				0.70
First TTE	33 ± 7	36 ± 7	0.16
Last TTE	35 ± 8*	36 ± 6	0.63
LVEF (%), mean ± SD				0.082
First TTE	64 ± 5	63 ± 6	0.63
Last TTE	62 ± 8	64 ± 6	0.19
LAVI (ml/m2), median (IQR)				0.50
First TTE	33 (17-43)	46 (35-54)	0.005
Last TTE	50 (37-60)*	53 (42-66)	0.23
sPAP (mmHg), median (IQR)				0.58
First TTE	25 (22-31)	25 (23-31)	0.66
Last TTE	29 (25-37)*	31 (27-33)*	0.76
MV annulus (mm), mean ± SD				0.65
First TTE	36 ± 5	37 ± 4	0.36
Last TTE	38 ± 5*	39 ± 4*	0.66
Length AML (mm), mean ± SD				0.014
First TTE	23 ± 3	24 ± 4	0.25
Last TTE	24 ± 3*	25 ± 4*	0.12
Length PML (mm), mean ± SD				0.49
First TTE	15 ± 3	16 ± 3	0.15
Last TTE	17 ± 3*	18 ± 1*	0.35
Thickness AML (mm), mean ± SD				0.88
First TTE	4 ± 1	4 ± 1	0.16
Last TTE	5 ± 1*	5 ± 1*	0.37
Thickness PML (mm), mean ± SD				0.19
First TTE	4 ± 1	5 ± 1	0.003
Last TTE	5 ± 1*	6 ± 2*	0.063
Billowing height AML (mm), mean ± SD				0.99
First TTE	4 ± 2	5 ± 2	0.076
Last TTE	5 ± 3*	5 ± 3	0.64
Billowing height PML (mm), mean ± SD				0.46
First TTE	5 ± 2	6 ± 3	0.016
Last TTE	7 ± 2*	8 ± 3*	0.16

AML: anterior mitral leaflet; IQR: interquartile range; LAVI: left atrial volume index; LVEDD: left ventricular end-diastolic diameter; LVEF: left ventricular ejection fraction; LVESD: left ventricular end-systolic diameter; MR: mitral regurgitation; MV: mitral valve; PML: posterior mitral leaflet; SD: standard deviation; sPAP: systolic pulmonary artery pressure; TTE: transthoracic echocardiography.

^* P-value <0.05 within group: first versus last measurement, corrected for time between echocardiograms.