. 2022 Feb 23;12:788886. doi: 10.3389/fphar.2021.788886

TABLE 2.

Pathology score.

Pathology Score	Endothelial injury	Mesangial sclerosis	Mesangiolysis	Inflammatory infiltrate	Interstitial fibrosis
	Endothelial injury	Mesangial sclerosis	Mesangiolysis	Inflammatory infiltrate	Interstitial fibrosis
eNOS^−/−:VEGF^KD − dox	0.6 ± 0.25	1 ± 0.32	0 ± 0	0 ± 0	0.8 ± 0.2
eNOS^−/−:VEGF^KD + dox	3 ± 0.4 ^a	3.4 ± 0.4 ^a	1.6 ± 0.61 ^a	1 ± 0.4	1.6 ± 0.22 ^a
DM-VEGF^KD − dox	0 ± 0	0 ± 0	0 ± 0	1 ± 0	0 ± 0
DM-VEGF^KD + dox	0 ± 0	1 ± 0	0 ± 0	1 ± 0	0 ± 0

Semi-quantitative score: 0 = none; 1 = 1–25%; 2 = 26–50%; 3 = 51–75%;4 = 76–100% of glomerular or kidney section areas, as appropriate (Véniant et al., 1994; Gross et al., 2006; Veron et al., 2011).

Indicates p < 0.005 compared to eNOS^−/−:VEGF^KD − dox.